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FMD Programs Show Promise in Restoring Smell & Taste While Supporting Metabolic Health

At L-Nutra, we are committed to pioneering innovative, science-backed solutions that improve health and longevity. In February, a new study published in Cell Reports Medicine takes us one step further in advancing our mission by showcasing the significant benefits of the Fasting Mimicking Diet (FMD) for both sensory and metabolic health, demonstrating that periodic fasting can reverse smell impairment—a condition often linked to metabolic dysfunction.

STUDY HIGHLIGHTS

Study Highlights: A randomized cross-over study led by Drs. Alessandro Micarelli and Marco Alessandrini, in collaboration with Professor Valter Longo, revealed how periodic cycles of FMD can improve chemosensory perception (the ability to detect taste and smell), while also supporting overall metabolic health.

 

After six cycles of FMD, the results included:

 

Sensory Benefits:

  • Participants showed a dramatic reduction in smell sensitivity (hyposmia), dropping from 38.1% to 6.4% – these improvements were long-lasting, restoring taste and smell function over time.

 

Metabolic Health:

  • Reductions in blood glucose, insulin, IGF-1, and LDL cholesterol.
  • Over 20 pounds of fat loss in six months, without muscle loss.
  • Improved insulin sensitivity and reduced inflammation markers (CRP, ESR).

 

Medication Reduction:

  • 58–68% of diabetic participants reduced their diabetes medication.
  • 25–29% of those on blood pressure medication were able to lower their dosage.

Implications for Metabolic Disease Prevention

 

By restoring sensory function, FMD may help prevent unhealthy eating behaviors and reduce obesity-related health risks. This study further strengthens the connection between metabolism, inflammation, and chemosensory perception, highlighting that a decline in taste and smell functions due to obesity can be reversed through targeted dietary interventions.  


FMD as Part of a Comprehensive Lifestyle Approach

 

These results emphasize the importance of integrating FMD into a comprehensive health plan, such as with L-Nutra Health Programs. When combined with personalized dietetic oversight, medical monitoring, and laboratory reviews, these programs can deliver sustainable improvements in sensory and metabolic function.  

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“Our nutrition platform technology exploits evolution and three billion years of research & development to promote rejuvenation and cures from within. It combines our history and tradition with state-of-the-art science to guide the human body to repair, reprogram, and regenerate itself to keep people young and healthy.”

– Dr. Valter Longo, Founder of L-Nutra.

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