Since organisms arose, the waxing and waning of their food resources has
been a constant in nature. When food is scarce, this exerts compulsory
pressure on all life forms to respond – or risk extinction. And so it is that
through time, all species that survived have developed adaptive
mechanisms during fasting that confer a survival advantage. When food is
plentiful, the cells grow. When food is scarce, the cells stop growing and
enter into a protective and recycling mode that conserves energy and
optimizes cellular functions.

One key mechanism triggered by fasting is called autophagy. In fact, the discovery
and description of autophagy mechanisms was so monumental to understanding cellular
health that the discoverer won the 2016 Nobel Prize in Physiology or Medicine. As it turns out,
the mechanisms of autophagy and other survival processes are unsurprisingly similar in all species,
down to their molecular pathways. From simple organisms such as yeast and fruit flies, to more complex
organisms such as mice, other mammals, and humans, these pathways are conserved.

Specifically, during fasting, the body acts to conserve energy by minimizing any growth activities. This is achieved by shutting down the food signal sensors such as insulin-like growth factor-1 (IGF-1), the target of rapamycin (TOR), and protein kinase A (PKA) signaling. In scientific terms, this process is called “down-regulation of nutrient sensing pathways.” Fasting-induced reductions in IGF-1, TOR, and PKA signaling result in increased cellular maintenance and protection, including increased activation of stress resistance, removal and replacement of damaged or dysfunctional cellular parts, and reduction of oxidative damage and inflammation. So, these fasting responses promote resilience and protection from aging and diseases.

Here lies one of nature’s greatest untold stories. By emulating what has evolved in nature’s laboratory, we can leverage many of the benefits of fasting to promote health and longevity. This is L-Nutra’s vision. But why not just fast? Despite the potential benefits, fasting is hard to do. For many, it’s not safe to do. So, our research has been centered around nutri-technology that makes fasting safer, effective, easier, and more practical. In short, our Fasting Mimicking Technology uses carefully combined nutrients to mimic a water-only fast. This provides many of the benefits (such as invoking autophagy and other survival mechanisms that nature has granted us) and minimizes the burdens associated with traditional fasting. Moreover, using specialized Fasting Mimicking Technology formulations, we continue to reap the benefits of autophagy and stress resistance, as we target specific health conditions.

That’s the power of Fasting Mimicking Technology.



Since the stress of fasting and fasting-mimicking affect nearly every cell in an organism, emerging evidence points to the potential of a multitude of beneficial effects on cells and organ systems.




L-Nutra is constantly entering into scientific partnerships to develop and test the next generation applications of our Fasting Mimicking Technology. To date, we have more than 30 completed or ongoing research collaborations around the globe.

University of Southern California
Policlinico San Martino Genova
University of Genova, Italy
Policlinico Paolo Giaccone Palermo
University of Verona
University of Rome Tor Vergata
Leiden University
University Hospital Heidelberg, Heidelberg, Germany
Charité Universitätsmedizin Berlin
Indiana University
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Sapienza University, Rome, Italy
Leiden University Medical Centre, The Netherlands
University Hospital, “Policlinico Paolo Giaccone” of Palermo, Italy
Galway Clinic and National University of Galway (NUIG), Ireland
University of Miami
Stanford University School of Medicine
Ospedale Policlinico S. Martino, Genova, Italy