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SCIENTIFIC ARTICLES

Multisystem Health
CLINICAL STUDY
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nature communications. 2024;15(1):1309. PubMed PMID: 38378685.
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017;9(377). PubMed PMID: 28202779.
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015;22(1):86-99. PubMed PMID: 26094889.
Fasting-Mimicking-Diet Does Not Reduce Skeletal Muscle Function in Healthy Young Adults: A Randomized Control Trial. Eur J Appl Physiol. 2022;122(3):651-61. PubMed PMID: 35034194.
The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial. J Clin Med. 2023;12(5). PubMed PMID: 36902498; PMCID: PMC10003066.
Diabetes
CLINICAL STUDY
Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. 2024. PubMed PMID:38546821. https://link.springer.com/article/10.1007/s00125-024-06137-0
Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study. The Journal of clinical endocrinology and metabolism. 2022. PubMed PMID: 35661214.
Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients. Front Endocrinol (Lausanne) 14, 1143799 (2023). https://doi.org/10.3389/fendo.2023.1143799
PRE-CLINICAL STUDY
Fasting-Mimicking Diet Promotes Ngn3-Driven beta-Cell Regeneration to Reverse Diabetes. Cell. 2017;168(5):775-88 e12. PubMed PMID: 28235195.
Metabolism
CLINICAL STUDY
Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial. npj Metabolic Health and Disease. 2023;1(1). doi: https://doi.org/10.1038/s44324-023-00002-1.
An Intermittent Fasting Mimicking Nutrition Bar Extends Physiologic Ketosis in Time Restricted Eating: A Randomized, Controlled, Parallel-Arm Study. Nutrients. 2021;13(5). PubMed PMID: 33946428; PMCID: PMC8147148.
Multiple Sclerosis
PRE-CLINICAL STUDY
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016;15(10):2136-46. PubMed PMID: 27239035.
Inflammatory Bowel Diseases
PRE-CLINICAL STUDY
Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019;26(10):2704-19 e6PubMed PMID: 30840892.
Alzheimer’s Disease
PRE-CLINICAL STUDY
Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022;40(13):111417. PubMed PMID: 36170815.
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging cell. 2013;12(2):257-68. PubMed PMID: 23362919.
Depression
CLINICAL STUDY
Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial. J Clin Psychol. 2020;76(10):1807-17. PubMed PMID: 32394438.
Cancer
PRE-CLINICAL STUDY
Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020;583(7817):620-4. PubMed PMID: 32669709.
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nature communications. 2020;11(1):2332. PubMed PMID: 32393788.
Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature communications. 2020;11(1):3083. PubMed PMID: 32576828.
Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial. Breast Cancer Res Treat. 2021;185(3):741-58. PubMed PMID: 33179154.
PRE-CLINICAL STUDY
Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial. International journal of cancer Journal international du cancer. 2023. PubMed PMID: 37615485.
Cyclic fasting-mimicking diet plus bortezomib and rituximab is an effective treatment for chronic lymphocytic leukemia. Cancer research. 2024. doi: 10.1158/0008-5472.CAN-23-0295. PubMed PMID: 38241703.

“Our nutrition platform technology exploits evolution and three billion years of research & development to promote rejuvenation and cures from within. It combines our history and tradition with state-of-the-art science to guide the human body to repair, reprogram, and regenerate itself to keep people young and healthy.”

– Dr. Valter Longo, Founder of L-Nutra.

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