The science behind longevity and medical nutrition therapy
L-Nutra's Fasting Mimicking Diet (FMD) was created by Dr. Valter Longo and developed with the Longevity Institute at USC, building on 25+ years of his research, backed by more than $36 million in National Institutes of Health and European Union funding. It is the subject of 41 human clinical trials, completed and ongoing.
Our research spans 42 collaborations with universities, medical centers, and research institutes, including Stanford, Mayo Clinic, Cedars-Sinai, Charité Berlin, and Leiden University Medical Center. A 2025 randomized pilot trial found that the FMD increased autophagic flux, a marker of cellular renewal, in human immune cells.
Most read articles and studies
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk (Nature Communications, 2024)
Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control (Diabetologia, 2024)
Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects (GeroScience, 2025)
Explore the research
Our science has been published in leading scientific and medical journals, from foundational laboratory research to clinical trials. Browse a selection below.
The FMD is the only nutrition program supported by preliminary data confirming autophagy activation in humans
+A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy
+Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
+Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease: controlled trial
+Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial
+A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
+The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial
+Fasting Mimicking Diet Cycles vs a Mediterranean Diet and Cardiometabolic Risk in Overweight and Obese Hypertensive Subjects: A Randomized Clinical Trial
+Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial
+Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality
+An Intermittent Fasting Mimicking Nutrition Bar Extends Physiologic Ketosis in Time Restricted Eating: A Randomized, Controlled, Parallel-Arm Study
+Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis
+Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
+Fasting and cancer treatment in humans: A case series report
+Fasting-mimicking diet and hormone therapy induce breast cancer regression
+Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence
+Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
+Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
+Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression
+A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
+Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control.
+Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes
+From the pioneers in longevity science
The Fasting Mimicking Diet is patented technology designed to support longevity and healthspan while preserving lean body mass.
Decades of studies on longevity and nutrition
Conducted with world-leading institutions
Conducted with world-leading institutions
For optimizing longevity and healthspan
